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EMA suspends Picato as a precaution while review of skin cancer risk continues

In September 2019, at the request of the European Commission, the European Medicines Agency's safety committee (the Pharmacovigilance Risk Assessment Committee - PRAC) commenced a review of data on skin cancer in patients using Picato (ingenol mebutate), a gel indicated for the treatment of cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults. The product information includes a warning in relation to keratoacanthoma and was updated to also include basal cell ca » read more

Influenza season 2019-2020 early situation assessment from ECDC and WHO Euro

Please find a link to the ECDC/WHO early situation assessment for the 2019/2020 influenza season which was released today Wednesday December 18. » read more

Antiviral notice to Health Care Professionals - Influenza

The most recent influenza surveillance data indicate that influenza-like illness (ILI) has increased in the community in the past week. The influenza-like illness (ILI) rate during week 49 (week ending December 8th 2019) was 37.5 per 100,000 population which is now above the Irish baseline ILI threshold of 18.1 per 100,000 for the first time this season. » read more

Recommendations to avoid potentially fatal dosing errors when using methotrexate for inflammatory diseases

Pfizer Direct Healthcare Professional Communication » read more

Pregabalin and Gabapentin Medicinal Products designated interchangeable

In line with its remit under the Health (Pricing and Supply of Medical Goods) Act 2013, the Health Products Regulatory Authority (HPRA) will include pregabalin and gabapentin-containing medicinal products on the List of Interchangeable Medicines. » read more

European Medicines Agency review of Xeljanz (Article 20 Referral)

The European Medicines Agency's safety committee (PRAC) has concluded a review of Xeljanz (tofacitinib) and recommended updates to product information and new risk minimisation measures. » read more

Preparation of infant formula

Regional Department of Public Health colleagues have notified HPSC of a number of cases of verocytotoxigenic E. coli (VTEC) in infants. » read more

ECDC Rapid Risk Assessment: Zika virus disease in Var department, France

On 1 October 2019, a case of locally acquired Zika virus (ZIKV) disease in France (Hyères city, Var department) was laboratory confirmed. » read more

Guidance on dealing with Tamoxifen shortage

As you may be aware, there is an on-going intermittent shortage of supply of tamoxifen in Ireland. This is being caused by an international shortage of the active pharmaceutical ingredient. It is not related to Brexit. » read more

XDR-typhoid travellers returning from Pakistan

There is an ongoing outbreak of extensively drug-resistant typhoid (XDR-typhoid), resistant to ampicillin, trimethoprim/sulphamethoxazole, chloramphenicol, fluoroquinolones and ceftriaxone, in Sindh province, Pakistan since late 2016, with over 10,000 cases reported to date. » read more

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